| 摘要 |
Malignant gliomas are treated by modifying the eicosanoid biosynthetic pathway with reduction of the inhibitory effect of prostanoids on the cytotoxic activity of NK and LAK cells. Synthetic peptides, corresponding to shared sequences with phospholipase activating protein (PLAP), having the capacity to activate phospholipase A2 (PLA2), when administered in a delayed release delivery system, such as with agarose beads induce release of PGE2, with significant tumor necrosis. A tumor model comprising an air pouch in the dorsum of rats is utilized for effective evaluation of the treatment, with tumor growth, treatment and evaluation of tumors grown therein.
|
