发明名称 |
Cancer therapy utilizing malignant cells expressing HSV-TK |
摘要 |
A method is provided for eliminating cancer cells from a population of cells containing cancer cells and noncancerous cells in vitro or in vivo comprising: (a) providing a mixture of noncancerous cells and cancer cells; (b) contacting the cancer cells with transgenic cancer cells comprising a foreign gene such as the herpes virus thymidine kinase gene that renders the transgenic cancer cells susceptible to a therapeutic agent; and (c) contacting the transgenic cancer cells with an amount of said therapeutic agent effective to kill both the transgenic cancer cells and the cancer cells.
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申请公布号 |
US5601818(A) |
申请公布日期 |
1997.02.11 |
申请号 |
US19940351891 |
申请日期 |
1994.12.08 |
申请人 |
UNIVERSITY OF ROCHESTER |
发明人 |
FREEMAN, SCOTT M.;ABRAHAM, GEORGE N.;MCCUNE, CRAIG S.;MOOLTEN, FREDERICK L.;KOEPLIN, DAVID |
分类号 |
A61K31/52;A61K31/522;A61K31/70;A61K35/12;A61K39/00;A61K48/00;A61P35/00;C07D473/18;C12N5/00;C12N5/06;C12N5/10;C12N15/09;(IPC1-7):A61K48/00;C12N15/00 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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