发明名称 |
One vessel stereoselective glycosylation of purines and pyrimidines |
摘要 |
A process for the preparation of 2',3' dideoxynucleosides, 2'-deoxynucleosides, and 2',3'-dideoxy-2',3'-didehydronucleosides is provided that includes the synchronous addition of a stereoselecting moiety (a directing group) and a protected purine or pyrimidine base to 5-(S)-6-(protected-oxy)-4,5-dihydrofuran in the presence of a Lewis acid. This one vessel reaction eliminates the need to separately prepare and purify a 2'-substituted ribose derivative that in a second step is condensed with a purine or pyrimidine base. The process can be easily modified to increase the stereoselectivity of formation of the beta -anomeric nucleoside as necessary.
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申请公布号 |
US5602245(A) |
申请公布日期 |
1997.02.11 |
申请号 |
US19920970691 |
申请日期 |
1992.11.04 |
申请人 |
EMORY UNIVERSITY |
发明人 |
WURSTER, JULIE;LIOTTA, DENNIS C.;WANG, JIANYING;WILSON, LAWRENCE J. |
分类号 |
C07H19/04;C07H19/06;C07H19/16;(IPC1-7):C07H1/00;C07H19/00;C07C313/14;C07D305/10 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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