发明名称 |
Manufacturing method and apparatus for biological probe arrays using vision-assisted micropipetting |
摘要 |
A method and apparatus is provided for spotting a biological probe onto an array. A micropipette containing a quantity of the biological probe in solution is manipulated to a position above a selected location within the array. The micropipette is pressurized sufficiently to produce a droplet of the biological probe at an open tip of the micropipette. Formation of the droplet is simultaneously visually monitored during the pressurization of the micropipette in order to estimate a volume measurement of the droplet. Upon reaching a predetermined volume for the droplet, the pressurizing of the micropipette is discontinued. The droplet of the predetermined volume is then dispensed onto the selected location.
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申请公布号 |
US5601980(A) |
申请公布日期 |
1997.02.11 |
申请号 |
US19940311374 |
申请日期 |
1994.09.23 |
申请人 |
HEWLETT-PACKARD COMPANY |
发明人 |
GORDON, GARY B.;CONRADSON, SCOTT A.;LICHTENWALTER, KAY |
分类号 |
B01L3/02;G01N35/00;G01N35/10;(IPC1-7):G01N35/10 |
主分类号 |
B01L3/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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