Dominant negative chimeras of the steroid/thyroid superfamily of receptors

摘要

PCT No. PCT/US90/03113 Sec. 371 Date May 10, 1993 Sec. 102(e) Date May 10, 1993 PCT Filed May 25, 1990Disclosed are novel trans-repressing analog receptors wherein the ligand-binding domain(s) are modified versus wild type receptor, such novel receptors having repressed trans-activation transcription activation properties. Also disclosed are recombinant methods and means for preparing such receptors and assays using such receptors.