| 发明名称 |
Recombinant pseudomonas exotoxin with increased activity |
| 摘要 |
This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.
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| 申请公布号 |
US5602095(A) |
申请公布日期 |
1997.02.11 |
| 申请号 |
US19950405615 |
申请日期 |
1995.03.15 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PASTAN, IRA H.;FITZGERALD, DAVID J. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/22;A61K39/395;A61P35/00;C07K14/21;C07K14/495;C07K16/28;C07K16/30;C07K19/00;C12N1/21;C12N15/31;C12P21/02;C12R1/19;C12R1/38;(IPC1-7):C07K14/21 |
主分类号 |
C12N15/09 |
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