摘要 |
A method of treating inflammation including administering to a subject an effective amount of a compound of the following formula: <IMAGE> wherein m is 1-4; and each of A and B, independently, is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, (CH2)nCHO, (CH2)oCOOH, C1-7 alkoxy, C2-7 alkoxyalkyl, C1-7 hydroxyalkyl, CN, NO2, halogen, CH(OR1)2, CO.R1, NR2R3 or its acid salt, CO.NR2R3, CHR1NR2R3 or its acid salt, CH=NR2, C 3BOND CR4, CR1=CR5R6, CO.CH=CHR7, CH=CHR8, or COOR9; in which each of n and o, independently, is 0-4; R1 is C1-4 alkyl or C1-4 acyl; each of R2 and R3, independently is H, C1-4 alkyl, or C1-4 hydroxyalkyl; R4 is H, C1-4 alkyl, C2-4 alkenyl, COR2, COOR10, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C1-4 halogenated alkyl; OR1, NHR7; each of R5 R6, independently, is H, CHO, COR1, COOH, COOR9, CN, or halogen; R7 is H, C1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R8 is COOR2, CO.CHO, C1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R9 is H, C1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2 -thienyl.
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