| 摘要 |
PROBLEM TO BE SOLVED: To obtain an aromatic cyanomethylamine useful as a raw material or intermediate for various pharmaceuticals, agrochemicals, polymer additives and other reagents in high selectivity and conversion. SOLUTION: The objective aromatic cyanomethylamine is e.g. m- or p- cyanobenzylamine. The compound can be produced by pretreating a Raney catalyst such as Raney nickel or a modified Raney nickel containing nickel and/or cobalt and selectively reducing one nitrile group of an aromatic dinitrile such as isophthalonitrile with hydrogen in the presence of the pretreated catalyst. The pretreatment is preferably carried out in a solvent comprising an aliphatic or alicyclic alcohol or ether, etc., in hydrogen, carbon monoxide or inert gas atmosphere or in an atmosphere containing the above gas at a partial pressure of 0.1-30kg/cm<2> at room temperature to 200 deg.C. In the above process, the pretreatment of the catalyst is carried out in the presence of 1-100wt.% of an alkali based on the catalyst. |
