| 摘要 |
Factor VIII:C polypeptide analogs are provided that are native Factor VIII:C polypeptides that contain modifications wherein the modifications comprise the alteration of the metal-binding properties of the molecule. Nucleic acid molecules encoding Factor VIII:C polypeptide analogs, vectors and host cells containing such nucleic acid molecules are also provided. Further provided are analog complexes that contain at least two such analogs. Methods of producing the analog, the analog complex, the nucleic acids, vectors, and host cells are also provided as well as methods of using such compositions for prevention or treatment of active Factor VIII:C polypeptide deficiencies. |
