<p>Castanospermine (I) is prepared by starting from 5-(t-BOC)amino-5-deoxy-1,2-O-isopropylidene- alpha -D-glucuronolactone. Two additional carbons are added to the starting material using ethyl acetate and a strong base and the resulting cyclic hemiketal is subjected to a series of reductions, with intervening removal of protecting groups, to give the castanospermine. A substituted hydroxypyrrolidinone and a substituted hydroxypyrrolidine serve as intermediates in the process. <CHEM> -</p>
申请公布号
DE69120108(T2)
申请公布日期
1997.02.06
申请号
DE1991620108T
申请日期
1991.03.11
申请人
MERRELL DOW PHARMACEUTICALS INC., CINCINNATI, OHIO, US
发明人
ANZEVENO, PETER B., ZIONSVILLE, INDIANA 46077, US;CREEMER, LAURA J., INDIANAPOLIS, INDIANA 46234, US;ANGELL, PAUL T., INDIANAPOLIS, INDIANA 46268, US