LIVER-SPECIFIC ADENOVIRUS EXPRESSION VECTOR

摘要

The invention concerns an adenovirus vector for liver-specific gene therapy. Areas of application include, in medicine, the treatment of genetic defects and tumour diseases of the liver, and molecular biology. The vector according to the invention is characterized in that a therapeutic gene which is coupled to a liver-specific promoter consisting of enhancer elements of the hepatitis B virus and an enhancer-less minimal promoter and is optionally surrounded by SAR elements is inserted in the adenovirus genome.