Assays to evaluate chemotherapeutic effectiveness of drugs

摘要

In vitro assays which respond to signal pathway modulating compounds in transformed cells are described. By measuring the effect of candidate drugs on specific kinase targets, successful candidates can be screened. Tumor biopsies can be assayed for susceptibility to treatment with a particular drug using similar assays. The VL30 controlled expression of a reporter gene can also be used in screening assays for both inhibitors and stimulators of cell proliferation.