| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new protein having a specific amino acid sequence, inducing the formation of cartilage from undifferentiated mesenchymal cell, exhibiting actions to promote the differentiation and maturation of osteoblast and useful for the treatment, prevention, etc., of osteoporosis, bone fracture, damage of tooth, wound, etc. SOLUTION: This new protein HMW(high-molecular weight) human MP52 is composed of the dimer of the peptide having the 1st to the 474th amino acid sequence of formula, the dimer of the peptide having the 121st to the 474th amino acid sequence of formula, the dimer of the peptide having the 122nd to the 474th amino acid sequence of formula, the dimer of the peptide having the 121st to the 474th amino acid sequence of formula and the 122nd to the 474th amino acid sequence of formula, the dimer of the peptide having the 1st to the 474th and the 121th (122nd) to the 474th amino acid sequence of formula, the dimer of the peptide having the 1st to the 474th and the 355th to the 474th amino acid sequence of formula and the dimer of the peptide having the 121st (122nd) to the 474th and the 355th to the 474th amino acid sequence of formula. The substance is useful for the prevention, treatment, etc., of osteoporosis, bone fracture, wound, etc. |
