摘要 |
Antibacterial compounds having the formula <IMAGE> (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is=CR6-; R1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R2 is selected from the group consisting of <IMAGE> <IMAGE> R3 is halogen; R4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R5 is hydrogen, loweralkyl, halo(loweralkyl), or -NR13R14; and R6 is halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl), as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
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申请人 |
ABBOTT LABORATORIES |
发明人 |
CHU, DANIEL T.;LI, QUN;COOPER, CURT S.;FUNG, ANTHONY K. L.;LEE, CHEUK M.;PLATTNER, JACOB J.;MA, ZHENKUN;WANG, WEI-BO |