发明名称 |
Optically pure 1-amido-2-indanols |
摘要 |
A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a trans-1-amino-2-hydroxycycloalkane to a cis-1-amino-2-hydroxycycloalkane. Methods for obtaining the trans-1-amino-2-hydroxycycloalkanes and their amides from alkenes are also disclosed. Novel, optically active 1-amido-2-indanols and 1-amino-2-alkanols are also disclosed.
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申请公布号 |
US5599985(A) |
申请公布日期 |
1997.02.04 |
申请号 |
US19940278459 |
申请日期 |
1994.07.21 |
申请人 |
SEPRACOR, INC. |
发明人 |
GAO, YUN;HONG, YAPING;NIE, XIAOYI;BAKALE, ROGER P.;FEINBERG, RICHARD R.;ZEPP, CHARLES M. |
分类号 |
C07C213/04;C07B61/00;C07C213/08;C07C215/44;C07C233/23;C07C233/74;(IPC1-7):C07C233/06 |
主分类号 |
C07C213/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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