发明名称 |
Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate |
摘要 |
The present invention is directed to a new hyperosmolar preservation solution useful in supporting the simultaneous in vitro growth of, and preservation of vascular endothelial cells from large vessel and microvessel origins. In addition, the preservation solution of the present invention may be used for initial flushing, and as a perfusate for storage of organs intended for transplantation using a warm preservation technology at between 18 DEG C. to 35 DEG C. Among the components of the preservation solution are colloid, mucopolysaccharide, retinal-derived fibroblast growth factor and a high magnesium concentration. Also, the present invention is directed to a method for preserving, without extreme hypothermia, an organ intended to be transplanted using the preservation solution.
|
申请公布号 |
US5599659(A) |
申请公布日期 |
1997.02.04 |
申请号 |
US19950372782 |
申请日期 |
1995.01.13 |
申请人 |
BREONICS, INC. |
发明人 |
BRASILE, LAUREN;CLARKE, JOLENE |
分类号 |
A01N1/02;C12N5/071;(IPC1-7):A01N1/02;C12N5/00 |
主分类号 |
A01N1/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|