| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject terpene compound known as a component of SHOMA (Cimicifugae Rhizoma), exhibiting antibacterial action, action on circulatory system, sedative action, antiinflammatory action, antipyretic action, etc., and useful as an antiinflammatory agent, analgesic agent, etc., by extracting the rhizome of SAISHOMA (Cimicifuga boetida L.) with a proper solvent. SOLUTION: This new terpene compound is expressed by formula I (R" is β-xylosyl or tri-O-acetyl-β-xylosyl), formula II (R<2> is the same as R<1> ; R<3> is H or acetyl), formula III (R<4> is the same as R<1> ; R<5> and R<7> are each H or acetyl; R<6> is H or OH) or formula IV (R<8> is β-xylosyl; R<9> and R<11> are each H; R<10> is H or OH). The compound exhibits antibacterial action, action on circulatory system, sedative action, antiinflammatory action, antipyretic action, etc., and is useful as an active component for antiinflammatory agent, analgesic agent, etc. These compounds can be produced by pulverizing the rhizome of SAISHOMA, extracting with methanol, extracting the extract with n-hexane, n-butanol and ethyl acetate and purifying each extract by column chromatography. |
