发明名称 |
LIPID-DEPENDENT DIAGNOSTIC ASSAYS. |
摘要 |
<p>For use in a lipid-dependent diagnostic assay, a stable aqueous suspension of a phospholipid which normally has a hexagonal (HII) organization when dispersed in an aqueous medium without detergent, the suspension containing the phospholipid, a detergent, and an aqueous phase. In the stable suspension, the phospholipid remains in suspension at a temperature of 25 DEG C for at least one hour. The suspension is suitable for providing the phospholipid to an assay for lupus anticoagulants which includes the step of pre-incubating a test sample with the phospholipid. In a further aspect of the invention an assay is provided for use in determining whether a patient has a lupus anticoagulant, the assay including the steps of: a) obtaining first and second samples of the patient's plasma; b) incubating the first sample with the stable aqueous phospholipid suspension of the present invention; c) performing a lipid-dependent diagnostic assay on both the first and second samples, the assay producing a positive reading when used to assay a sample which contains lupus anticoagulants; and d) comparing the results of the assays performed on the first and second samples, the presence of a normal result for the first sample and a positive result for the second sample being indicative of the patient having a lupus anticoagulant.</p> |
申请公布号 |
GR3021412(T3) |
申请公布日期 |
1997.01.31 |
申请号 |
GR19960402783T |
申请日期 |
1996.10.23 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
JANOFF, ANDREW, S.;RAUCH, JOYCE |
分类号 |
C12Q1/56;G01N33/564;G01N33/86;G01N33/92;(IPC1-7):G01N33/86 |
主分类号 |
C12Q1/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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