| 摘要 |
PCT No. PCT/GB96/01478 Sec. 371 Date Dec. 18, 1997 Sec. 102(e) Date Dec. 18, 1997 PCT Filed Jun. 20, 1996 PCT Pub. No. WO97/01553 PCT Pub. Date Jan. 16, 1997The present invention provides compounds of formula (I), wherein R1 is a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulphur, which group is optionally substituted; R2 is hydrogen, halogen, C1-6alkyl, C1-6alkoxy, CF3, OCF3, NO2, CN, SRa, SORa, SO2Ra, CO2Ra, CONRaRb, C2-6alkenyl, C2-6alkynyl or C1-4alkyl substitued by C1-4alkoxy, where Ra and RaRb each independently represent hydrogen or C1-4alkyl; R3 is hydrogen, halogen, C1-6alkyl, C1-6-alkoxy substituted by C1-4alkoxy or CF3; R4, R5, R6, R9a, R9b, A, X and Y are as defined in the specification; and m is zero or , and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and pos therpetic neuralgia. |
