| 摘要 |
A prostaglandin having formula (I), (II), or (III): <CHEM> wherein R<1> indicates a C1 to C10 alkyl group, C3 to C8 cycloalkyl group, cyano group, formyl group, carboxyl group, (C1 to C5 alkyl)oxycarbonyl group, C2 to C7 alkanoyl group, or a C1 to C5 alkyl group substituted with (a) halogen atom(s) or phenyl group(s), Z indicates a hydrogen atom or OR<2>. R<2> and R<3> indicate a hydrogen atom, tri(C1 to C7 hydrocarbon)silyl group, or a group forming an acetal bond with the oxygen atom of a hydroxy group, R<4> indicates a C1 to C8 alkyl group, C2 to C8 alkenyl group, C2 to C8 alkynyl group, phenyl group, or C3 to C8 cycloalkyl group, Y indicates a C1 to C5 alkyl group or CO2R<5>, R<5> indicates a hydrogen atom, C1 to C10 alkyl group, C2 to C10 alkenyl group, or cations, X indicates a methylene group or oxygen atom. W indicates a sulfur atom, sulfynyl group, or methylene group, V indicates a sulfur atom or sulfynyl group, W<1> indicates a sulfur atom or methylene group, the mark -- indicates a double bond or single bond, a process of production thereof, and inhibitors of cell migration caused by chemokines containing (I) or (II) as an active ingredient. |
