发明名称 |
METHOD OF IDENTIFYING INHIBITORS OF THE JAK-STAT SIGNAL TRANSDUCTION PATHWAY |
摘要 |
Agents which inhibit the Jak-Stat signal transduction pathway are identified in order to identify candidate drugs for treatment of proliferative disorders. Identification methods are alternatively based on inhibiting the interaction of: (1) the activated Stat3 and Stat5 transcription factors with an electrophoretic mobility shift assay probe, or (2) the Stat3 or Stat5 proteins with the IL-2R beta chain of the IL-2 receptor.
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申请公布号 |
WO9703358(A1) |
申请公布日期 |
1997.01.30 |
申请号 |
WO1996US11206 |
申请日期 |
1996.07.02 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE;LEONARD, WARREN, J. |
发明人 |
LEONARD, WARREN, J. |
分类号 |
A61K38/00;C07K14/47;C07K14/715;C12Q1/68;G01N33/50;G01N33/569;G01N33/68;(IPC1-7):G01N33/50 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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