发明名称 |
GENERATION OF IMMUNE RESPONSES TO PROSTATE-SPECIFIC ANTIGEN (PSA) |
摘要 |
We have discovered that by using a recombinant viral vector, preferably a pox virus vector having at least one insertion site containing a DNA segment encoding prostate-specific antigen (PSA), operably linked to a promoter capable of expression in the host, a specific humoral and cellular immune response to PSA can be generated. The method preferably comprises introducing a sufficient amount of the recombinant pox virus vector into a host to stimulate the immune response, and contacting the host with additional PSA at periodic intervals thereafter. The additional PSA may be added by using a second pox virus vector from a different pox genus. In another embodiment, additional PSA can be added by contacting the host with PSA by a variety of other methods, including in one preferred embodiment adding PSA. The PSA may be formulated with an adjuvant or in a liposomal formulation.
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申请公布号 |
CA2226436(A1) |
申请公布日期 |
1997.01.30 |
申请号 |
CA19962226436 |
申请日期 |
1996.06.26 |
申请人 |
UNITED STATES GOVERNMENT, REPRESENTED BY THE DEPARTMENT OF HEALTH AND HU MAN SERVICES;THERION BIOLOGICS CORPORATION |
发明人 |
PANICALI, DENNIS L.;SCHLOM, JEFFREY |
分类号 |
C12N15/09;A61K39/00;A61K48/00;A61P35/00;C07K14/47;C07K16/40;C12N9/64;C12N15/00;C12N15/57;C12R1/92;(IPC1-7):A61K48/00;A61K31/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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