| 摘要 |
Quinoxaline- and quinoxalinylalkane-phosphonic acids of formula (I), wherein R1 is free or esterified carboxy or free or partially esterified phosphono, R2 and R3 are each independently of the other hydrogen or an aliphatic radical, the radicals R4, R5 and R6 are each independently of the others hydrogen, an aliphatic hydrocarbon radical, free or etherified hydroxy, free or etherified mercapto or oxidised free or etherified mercapto, unsubstituted or aliphatically substituted amino, nitro, free or esterified or amidated carboxy, cyano, free or amidated sulfamoyl, halogen or trifluoromethyl and X is a divalent aliphatic radical, and their tautomers and/or salts have NMDAantagonistic properties and can be used in the treatment of pathological conditions that are responsive to blocking of NMDA-sensitive receptors.
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