Improved process for synthesizing carbapenem intermediates

摘要

A process of synthesizing a compound of formula (1) or (2) is disclosed wherein R represents H or methyl and P represents triethylsilyl or trimethylsilyl. A compound of formula (3) or (4) is reacted with P-C1 wherein P is as defined above, in the presence of base and a substantially non-reactive solvent to produce (1) or (2).