LYSINE 1689 FACTOR VIII:C POLYPEPTIDE ANALOGS

摘要

Factor VIII:C polypeptide analogs are provided that are native Factor VIII:C polypeptides that include an Arg to Lys substitution at position 1689. Nucleic acid molecules encoding the Factor VIII:C polypeptide analogs, vectors and host cells containing such nucleic acid molecules are also provided. Further provided are analog complexes that contain the analog. Methods of producing the analog, the analog complex, the nucleic acids, vectors, and host cells are also provided as well as methods of using such compositions for prevention or treatment of active Factor VIII:C polypeptide deficiencies.