Phenothiazine cytokine inhibitors

摘要

New benzothiazine derivatives corresponding to the general formula I: <IMAGE> (I) in which: X represents halogen, n represents 0, 1, or 2, B represents the following formula: <IMAGE> (B) in which: R1 & R2 together with the carbons to which they are attached form a 6-carbon-atom aromatic ring which is optionally substituted by a group X' representing halogen, and Y represents the radical -(SO2)x-Alk-Z, x, Alk, and Z are as defined in the specification; as well as their possible stereoisomers, epimers, N-oxides and pharmaceutically-acceptable acid or base addition salts; and medicinal products containing the same, useful in the treatment of inflammatory disorders requiring an inhibitor of cytokines.