发明名称 |
Treatment with lys-plasminogen of reperfusion injury and brain edema caused by ischemia |
摘要 |
A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. The administration of lys-plasminogen alone, in a dosage of about 10-1000 caseinolytic units/kg, can be used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like. Lys-plasminogen can also lessen cerebral edema which results from cerebral ischemia.
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申请公布号 |
US5597800(A) |
申请公布日期 |
1997.01.28 |
申请号 |
US19940345468 |
申请日期 |
1994.11.21 |
申请人 |
IMMUNO AKTIENGESELLSCHAFT |
发明人 |
EIBL, JOHANN;PICHLER, LUDWIG;SCHWARZ, HANS-PETER |
分类号 |
A61K38/00;A61K38/43;A61K38/46;A61K38/48;A61P9/00;A61P9/10;(IPC1-7):A61K38/48 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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