RING-SHAPED DEVICES

摘要

The invention relates to a ring-shaped device comprising: (a) a first compartment comrising an non-medicated core of ethylene-vinylacetate copolymer, encircled by a steroid hormone loaded ethylen-vinylacetate copolymer layer, and a non-medicated outer layer of ethylene-vinylacetate copolymer; (b) a second compartment comprising a core of ethylene-vinylacetate copolymer loaded with a steroid hormone and a non-medicated outer layer of ethylene-vinylacetate polymer; and (c) optionally placebo segments of a thermo-plastic material separating the first from the second compartment. In a preferred embodiment the invention is related to a two-compartment vaginal ring, the first compartment comprising crystalline etonogestrel and the second compartment comprising a (sub)-saturated mixture of etonogestrel and ethinyl estradiol, both compartments optionally being separated from each other by placebo segments of high density polyethylene.