发明名称 |
TNF MODULATION |
摘要 |
Modulators such as proteins, peptides, antibodies or analogs, fragments or derivatives of any of them are provided which are capable of interacting with, or binding to, the intracellular domain of the membrane-bound form of TNF (26 KD TNF). These modulators are capable or regulating the expression, proteolytic processing, bioactivity or intracellular signaling of the 26 KD TNF and may thus be used for the treatment of diseases in which TNF plays a central role.
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申请公布号 |
WO9702345(A1) |
申请公布日期 |
1997.01.23 |
申请号 |
WO1996IL00039 |
申请日期 |
1996.07.04 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;WALLACH, DAVID;POCSIK, EVA;DUDA, ERNO |
发明人 |
WALLACH, DAVID;POCSIK, EVA;DUDA, ERNO |
分类号 |
A61K38/00;C07K14/47;C12N15/12;(IPC1-7):C12N15/12;C12N15/81;C12N1/21;C12Q1/68;A61K38/17;A61K48/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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