发明名称 Novel aminophenylphosphonic acid derivatives, process for their preparation and pharmaceutical compositions containing them
摘要 Amino phenyl phosphonic acid derivs. of formula (I), their isomers and acid or base addn. salts new. R1, R2 = H, halo, 1-6C alkyl, 1-6C alkoxy, nitro, or trihalomethyl; X = CO, SO2, or CH2; A = 1-20C alkylene with 0-6 double bonds and in which 1 or more CH2 gps. may be replaced by phenylene, naphthylene or anthracenylene (all opt. substd), 3-7C cycloalkylene, -phenylene-A3-phenylene-, carbazolediyl, N-(R5)-carbazolediyl, 9-thiofluorenediyl, 9-oxy-fluorenediyl, furandiyl, thiophenediyl, pyrrolediyl or N-(R5)-pyrrolediyl or a gp. of formula (i); q = 0-2; R3-R5 = H or 1-6C alkyl; A2 = bond, methylene, 1,2-ethylene, 1,3-propylene or ethenylene; A3 = bond, methylene, ethylene, -CH=CH- or -SO2-; 3 Cpds. (I) are specifically claimed e.g. : 4,4'-Ä1,4-divinylenebenzenediyl bis(carbonylamino)Übis(phenyl phosphonic) acid.
申请公布号 EP0754693(A2) 申请公布日期 1997.01.22
申请号 EP19960401594 申请日期 1996.07.18
申请人 ADIR ET COMPAGNIE 发明人 CORDI, ALEX;DESOS, PATRICE;MORRIS, ANGELA D.;ATASSI, GHANEM
分类号 A61K31/66;A61K31/665;A61K31/67;A61K31/675;A61P27/02;A61P35/00;C07F9/38;C07F9/40;C07F9/572;C07F9/655;C07F9/6553;(IPC1-7):C07F9/38 主分类号 A61K31/66
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