| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new cyclic diamine derivative having anticholinergic effect on smooth muscle, selectively of the action in other smooth muscle receptor higher than in cardiac muscarine and, useful as a therapeutic agent for a hypersensitive intestinal syndrome, etc. SOLUTION: This compound is shown by formula I [R<1> and R<2> are each phenyl, pyridyl, etc.; R<3> is H or a lower alkyl; R<4> and R<5> are each independently H, a lower alkyl, etc.; R<6> and R<7> are each independently H, a lower alkyl, etc.; R<8> is H, a halogen, etc.; R<9> is NR<10> R<11> (R<10> and R<11> are each independently H, a lower alkyl, etc.), etc.; Z is C or N; (m) is 1, 2, 3 or 4; (n) is 1, 2 or 3; (p) is 0, 1, 2 or 3] such as 4-(4-benzyl-1-piperazinyl)-2,2-diphenylacetic acid amide. The compound of formula I in which R<9> is NH2 is obtained by reacting a compound of formula II (X is an eliminable group) with a compound of formula III and hydrolyzing the prepared compound of formula IV. |
