| 摘要 |
PROBLEM TO BE SOLVED: To readily obtain an ω-formylcarboxylic acid ester useful in various fields as a main product in high yield by reacting a cycloalkanone with a nitrous acid ester in the presence of a Lewis acid. SOLUTION: (A) A cycloalkanone (e.g. cyclopentanone or cyclohexanone) is reacted with (B) a nitrous acid ester (e.g. methyl nitrite, ethyl nitrite, n-butyl nitrite or i-butyl nitrite) in the presence of a Lewis acid (preferably a boron trifluoride methanol complex, a boron trifluoride ether complex, etc.), preferably at -10 to +30 deg.C to afford (C) an ω-formylcarboxylic acid ester of the formula [R is a 1-6C alkyl or a 5-8C cycloalkyl; (n) is an integer of 4-11]. Furthermore, the component (B) is used in an amount of 1-8 equiv., preferably 2-5 equiv. based on the component (A). The Lewis acid is used in an amount of 0.01-0.5 equiv., preferably 0.05-0.1 equiv. based on the component (A). |
