| 摘要 |
Stabilized pulverulent active agents, compositions containing them and also process for obtaining them; such stabilized active agents enable dry and stable pharmaceutical, dietary, nutritional or cosmetic compositions to be obtained, in which the properties of the said active agents are neither modified nor impaired. Such stabilized active agents are stabilized by coating with a coating composition comprising: - at least one film-forming agent, in proportions of between 2 and 25% by weight of the final mass, selected from polyvinylpyrrolidones (povidone), polyvinyl alcohols, vinylpyrrolidone/vinyl acetate copolymer, vinylpyrrolidone/polyvinyl alcohol copolymer, cellulose derivatives such as cellulose acetate, cellulose acetate phthalate, cellulose butyrate, ethylcellulose and methylcellulose, acrylic and methacrylic polymers and copolymers and vegetable, animal or synthetic waxes, and - at least one pore-forming agent, in proportions of between 0 and 5%, by weight preferably of between 0.5 and 5%, of the final mass, selected from microcrystalline lactose, low molecular weight polyethylene glycols, calcium carbonate, calcium phosphate, sucrose, sodium chloride and potassium chloride. The stabilized pulverulent active product, in the form of microparticles, possesses a particle size of between 50 and 1000 mu m, and preferably between 200 and 500 mu m.
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