| 摘要 |
PROBLEM TO BE SOLVED: To readily produce the subject compound useful as an intermediate for medicines and agrochemicals in high yield by reacting esters having methylene group at the α-position with a phthalic acid ester derivative in the presence of a base. SOLUTION: (A) Esters of the formula R<1> CH2 CO2 R<2> (R<1> is a 1-10C alkyl, a 2-10C alkenyl or a 2-10C alkynyl; R<2> is a 1-4C alkyl) are reacted with (B) a phthalic acid ester derivative of formula I (R<3> is a 1-4C alkyl; R<4> to R<7> are each independently H, a 1-10C alkyl, a 2-10C alkenyl, a 1-10C alkoxyl or a halogen) in the presence of a base to thereby afford (C) a 2-substituted-1,3- indanedione derivative of formula II. A hydride or an alkoxide of a group I or II metal of the periodic table is preferably used as the base. For example, ethyl butyrate can be reacted with diethyl phthalate in the presence of sodium hydride to provide 2-ethyl-1,3-indanedione. |
