发明名称 |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
摘要 |
Replacement of the natural nucleotides with unnatural zwitterionic nucleotides having a cationic moiety tethered to the base (or analog thereof) results in oligodeoxynucleotides with diminished charge but undiminished ability to complex with DNA at low ionic strengths. We have now discovered that DNA can be made fully zwitterionic by introducing tethered cationic moieties to the bases without affecting duplex formation. The resulting oligonucleotides have the further advantages of being nuclease resistant.
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申请公布号 |
US5596091(A) |
申请公布日期 |
1997.01.21 |
申请号 |
US19940214603 |
申请日期 |
1994.03.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SWITZER, CHRISTOPHER |
分类号 |
C07H21/00;C12N15/113;(IPC1-7):C07H21/04;C12Q1/68;C12P19/34 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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