COLCHICINE DERIVATIVES, THE USE THEREOF AND FORMULATIONS CONTAINING THEM

摘要

The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, anti-inflammatory and muscle relaxant activities; said derivatives include novel colchine nitrogen amides for use either as such or after derivatization of the hydroxyl at C3 of the aromatic ring and at C10 of the tropolone ring. These novel compounds have a cytotoxicity on human tumoral cell lines comparable with colchicine but, in comparison with the latter, they are much more active on cells resistant to the usual antiblastics. The compounds can be included in pharmaceutical formulations useful for the intravenous, oral and topical administrations.