TRIAZOLE ANTIFUNGAL AGENTS

摘要

An antifungal agent of the formula:- (see formula I) or a pharmaceutically acceptable salt thereof, where Ar is a phenyl group substituted by 1 to 3 substituents each independently selected from halo and CF3; and X is a group of the formula:- wherein "Het" is selected from (a) an unsubstituted 1,2,3-triazol-1-yl group , (b) an unsubstituted 1,2,4-triazol-1-yl or -4-yl group, (c) a 1,2,3- or 1,2,4- triazolyl group attached to the adjacent phenyl group by a carbon atom and optionally substituted on a nitrogen atom by C1-C4 alkyl, or (C1-C4 alkoxy)methyl, (d) unsubstitute d imidazol-1-yl, (e) an unsubstituted pyrazol-3-yl group, an unsubstituted pyrazol-4-yl group or 1-methylpyrazol-5-yl group, and (f) an imidazol-4-yl or 1- methylimidazol-5-yl group.