| 摘要 |
The present invention provides compounds of formula (I), wherein R1 is phenyl or a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms, selected from nitrogen, oxygen and sulphur, which aryl or heteroaryl group is optionally substituted; R2 is hydrogen, halogen, C16alkyl, C1-6alkoxy, CF3, OCF3, NO2, CN, SRa, SORa, SO2Ra, CO2Ra, CONRaRb, C26alkenyl, C2-6alkynyl or C1-4alkyl substituted by C1-4alkoxy, where Ra and Rb each independently represent hydrogen or C1-4alkyl; R4, R5, R6, R9a and R9b, A, X, and Y are as defined in the specification; the dotted line is an optional double bond; Q1 is oxygen, sulphur or -NH-; Q2 is -N=, -NH-, -CH= or CH2-; and m is zero or 1; and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
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