4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS

摘要

The present invention relates to a compound of formula (I), wherein R1 represents hydrogen or an optionally substituted hydrocarbon group; R2 represents an optionally substituted hydrocarbon group, an optionally substituted amino group or a substituted hydroxyl group; X represents an optionally halogenated lower alkylene group; Y represents a substituent; n represents an integer of 0 to 6; and m represents 0 or 1; or a salt thereof, a process for producing the compound of formula (I) which comprises subjecting a compound of formula (II), wherein all symbols are as defined above or a salt thereof to acylation or reaction with an isocyanate, and if necessary, subjecting the resultant compound to oxidation and/or substituent-exchange reaction, a compound of formula (III), wherein all symbols are as defined above, or a salt thereof, and use of a compound of formula (I) for manufacturing a pharmaceutical composition for treating or preventing diseases relating to the action of melatonin in mammals.