发明名称 |
Inhibitors of TNF- alpha secretion |
摘要 |
Compounds and methods are disclosed that are useful in inhibiting the TNF- alpha converting enzyme (TACE) responsible for cleavage of TNF- alpha precursor to provide biologically active TNF- alpha . The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.
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申请公布号 |
US5594106(A) |
申请公布日期 |
1997.01.14 |
申请号 |
US19940292547 |
申请日期 |
1994.08.18 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
BLACK, ROY A.;FITZNER, JEFFREY N.;SLEATH, PAUL R. |
分类号 |
A61K38/00;C07C259/06;C07K5/02;C07K5/06;C07K5/065;C07K5/068;C07K5/072;(IPC1-7):A61K31/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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