| 摘要 |
Pharmaceutical preparation of a non-glycosylated t-PA derivative K1K2P pro with an enzymatic activity of at least 0.4 MU/ml. and a pH value of 4.5 to 6, which contains citrate and at least one compound from the group consisting of a) ascorbic acid, b) EDTA, c) amino compounds of the formula R1R whereby X = SO3H, CH(NH2)-CO2H, CO2H, H, NH2 or OH, R = C1-C9-alkylene, C3-C6-cycloalkylene or benzylidene and R1 and R another, are H or C1-C3-alkyl, d) guanidinobutyric acid, e) dimethylbiguanide, f) arginine, g) glucosamine, fructose, h) pyrimidine nucleosides and pyrimidine nucleotides, i) carboxylic acids substituted with one or more hydroxyl, keto and/or further carboxyl groups, as well as medicaments based on the t-PA derivative K1K2P pro as active material and processes for their production.
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