Compound with platelet aggregation inhibitor activity

摘要

PCT No. PCT/JP94/00437 Sec. 371 Date Jan. 30, 1995 Sec. 102(e) Date Jan. 30, 1995 PCT Filed Mar. 17, 1994 PCT Pub. No. WO94/21599 PCT Pub. Date Sep. 29, 1994A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: <IMAGE> (I) wherein R1 represents a group -W-(CH2)i-COOR3, R2 represents a hydrogen atom or a group -W-(CH2)i-COOR3 or -OR4, X represents -CH= or -N=, Y represents (i) a group -(CO)k-N(R5)-Z-, wherein Z represents a bond or a group -(CH2)m-CO- or a group -(CH2)m-CHR6-, (ii) a group -(CH2)m-N(R5)-(CO)k-, or (iii) a group -(CO)k-Het, wherein Het represents a five- or six-membered heterocyclic ring comprising a nitrogen atom, A represents (i) the following groups (III) or (IV) <IMAGE> (III) <IMAGE> (IV) B represents a bond, C1-6 alkylene or C2-6 alkenylen.