Method of treating septic shock by preventing actin polymerization

摘要

A method of treating septic shock in a mammal by preventing in vivo polymerization of actin in the mammal. An actin antipolymerizer such as thymosin beta 4 (T beta 4) is administered to the mammal so as to treat septic shock in the mammal. The amount of T beta 4 administered is sufficient to reduce levels of IL-1 alpha , TNF alpha , PAF, Tx beta 2 and/or 6-keto-PGF1 alpha in the blood of the mammal. Also disclosed is a method of preventing septic shock in a mammal following endotoxin introduction in the mammal by administrating an actin antipolymerizer such as T beta 4.