Peptides and peptide analogues of the 65 kD isoform of human glutamic acid decarboxylase are provided for use in the treatment and prevention of diabetes. Peptide analogues contain generally from one to three amino acid alterations. Peptides and analogues may be used to diagnose diabetes and detect a predisposition to diabetes.
申请公布号
WO9700891(A1)
申请公布日期
1997.01.09
申请号
WO1996US10790
申请日期
1996.06.24
申请人
NEUROCRINE BIOSCIENCES, INC.;KENNEDY INSTITUTE OF RHEUMATOLOGY;ST. BARTHOLOMEW'S HOSPITAL CENTRE FOR CLINICAL RES
发明人
LONDEI, MARCO;LESLIE, R., DAVID, G.;CONLON, PAUL, J.;LING, NICHOLAS;GAUR, AMITABH