发明名称 |
Conjugates of alphamsh with a fatty acid, preparation method therefor, and use thereof as a drug |
摘要 |
A peptide conjugate comprising a peptide sequence that includes at least one sequence of four alpha MSH-derived amino acids optionally in a natural form, said sequence being chemically or physically conjugated with acids selected from either dicarboxylic acids of general formula (I): HOOC-R1-COOH, wherein R1 is a straight or branched alkylene radical having at least 3 and preferably 3-10 carbon atoms, and being optionally substituted, in particular by one or more amino or hydroxy groups; or alpha -monounsaturated fatty acids with a cis or preferably trans configuration, of general formula (II): R2-CH=CH-COOH, wherein R2 is a straight or branched alkyl radical having at least 6 and preferably 6-10 carbon atoms, and being substituted by an amino, hydroxy or oxo group. |
申请公布号 |
AU6309496(A) |
申请公布日期 |
1997.01.09 |
申请号 |
AU19960063094 |
申请日期 |
1996.06.12 |
申请人 |
SOCIETE D'ETUDE ET DE RECHERCHE DE PATHOLOGIE APPLIQUEE - SERPA |
发明人 |
LUCIEN DUSSOURD D'HINTERLAND;ANNE-MARIE PINEL |
分类号 |
A61K8/00;A61K8/36;A61K8/362;A61K8/365;A61K8/44;A61K8/64;A61K8/72;A61K38/00;A61P37/08;C07K7/06;C07K14/685 |
主分类号 |
A61K8/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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