发明名称 |
NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES |
摘要 |
A camptothecin analogue characterised in that the hydroxy lactone of the camptothecin is a beta -hydroxy lactone or the corresponding beta -hydroxyacid, resulting from the opening of said lactone, or a derivative of said beta -hydroxyacid, or a pharmaceutically acceptable salt thereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing the compounds of formulae (I) and (II), pharmaceutical compositions containing said compounds, and their use, particularly as topoisomerase inhibitors and antitumoral drugs, are also disclosed. |
申请公布号 |
WO9700876(A1) |
申请公布日期 |
1997.01.09 |
申请号 |
WO1996FR00980 |
申请日期 |
1996.06.21 |
申请人 |
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION;BIGG, DENNIS;LAVERGNE, OLIVIER;PLA RODAS, FRANCESC;POMMIER, JACQUES;ULIBARRI, GERARD |
发明人 |
BIGG, DENNIS;LAVERGNE, OLIVIER;PLA RODAS, FRANCESC;POMMIER, JACQUES;ULIBARRI, GERARD |
分类号 |
A61K31/47;A61K31/4745;A61K31/475;A61K31/496;A61K31/5377;A61P31/12;A61P33/00;A61P33/02;A61P35/00;A61P43/00;C07D209/00;C07D213/02;C07D213/61;C07D213/64;C07D213/66;C07D215/08;C07D221/00;C07D313/00;C07D413/10;C07D471/14;C07D487/04;C07D491/04;C07D491/044;C07D491/22;C07D498/14;(IPC1-7):C07D491/22 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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