| 摘要 |
<p>PCT No. PCT/DE91/00620 Sec. 371 Date Jun. 18, 1992 Sec. 102(e) Date Jun. 18, 1992 PCT Filed Jul. 30, 1991 PCT Pub. No. WO92/03571 PCT Pub. Date Mar. 5, 1992.A process for the production of 4-pregnene-3,20-dione and its derivatives of general formula I <IMAGE> (I) in which R1 means a hydrogen atom, a fluorine atom or a methyl group, R2 represents a hydrogen atom or a hydroxy group, and R3 and R4 together symbolize a carbon-carbon bond or R3 represents a hydrogen atom, a hydroxy group or an alkanoyloxy group with up to 6 carbon atoms and R4 means a hydrogen atom or a methyl group, is described, which is characterized in that a pregnane derivative of general formula II <IMAGE> (II) in which R1, R3 and R4 have the above-mentioned meaning, symbolizes a single bond or a double bond, R5 represents a hydrogen atom, a hydroxy group or an alkanoyloxy group with at most 6 carbon atoms and R6 means a hydrogen atom or an alkanoyl group with at most 6 carbon atoms, is fermented with a bacterial culture of species Mycobacterium spec. NRRL B-3805.</p> |
