| 摘要 |
PURPOSE: To obtain the subject new substance from a culture product prepared by culturing an actinomyces RK-16 belonging to the genus Streptomyces, having a returning action of a cell transformed with a temperature sensitive cancer gene v-src to a normal state, useful as an antitumor agent, etc. CONSTITUTION: This new nucleoside derivative substance is shown by the formula (R1 is H or methyl; R2 is H or pyrrolidine-2-carbonyl; with the proviso that a case in which R1 is methyl and R2 is pyrrolidine-2-carbonyl is omitted) (e.g. phosmidosine-A, etc.). The substance has an action of returning a srcts-NRK cell obtained by transforming a normal rat nephrocyte with a temperature sensitive cancer gene v-src to a normal state and is useful as an antitumor agent, etc. The nucleoside substance is obtained by inoculating an actinomyces RK-16 strain (FERM P-9196) belonging to the genus Streptomyces into a medium, culturing and collecting the product from the culture substance. |
