Measurement of an enzyme marker as an aid to diagnosis of liver transplant rejection

摘要

A method which assists in the early diagnosis of rejection in a liver transplant recipient comprises measuring an increase in plasma or serum alpha glutathione S-[tranferase]transferase( alpha -GST) from said recipient in the absence of or preceding any change in plasma or serum transaminase. alpha -GST is most suitably measured by enzymeimmunoassay, using a solid phase antibody which is monospecific for alpha -GST. The monospecific antibody cross-reacts with the alpha -GST dimers B1B1, B1B2 and B2B2.