Benzimidazoles useful as angiotensin-11 antagonists

摘要

Disclosed herein are angiotensin-II antagonists of the formula <IMAGE> wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R3 is, inter alia, lower alkyl; and, R4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1 -yl]methyl]-biphenyl-2-carboxylic acid.